Air pollution, white matter microstructure, and brain volumes Periods of susceptibility from pregnancy to preadolescence

0269-7491/© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Air pollution, white matter microstructure, and brain volumes: Periods of susceptibility from pregnancy to preadolescence☆ Anne-Claire Binter a,b,c, Michelle S.W. Kusters a,b,c,d, Michiel A. van den Dries a,b,c,d, Lucia Alonso a,b,c, Małgorzata J. Lubczyńska a,b,c, Gerard Hoek e, Tonya White d,f, Carmen Iñiguez c,g,h, Henning Tiemeier d,i, j, Mònica Guxens a,b,c,d,* a ISGlobal, Barcelona, Spain b Universitat Pompeu Fabra (UPF), Barcelona, Spain c CIBER Epidemiología y Salud Pública (CIBERESP), Spain d Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, Erasmus University Medical Centre, Rotterdam, the Netherlands e Institute for Risk Assessment Sciences, Utrecht University, the Netherlands f Department of Radiology and Nuclear Medicine, Erasmus University Medical Centre, Rotterdam, the Netherlands g Department of Statistics and Operational Research, Universitat de València, Spain h Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, València, Spain The Generation R Study Group, Erasmus University Medical Centre, Rotterdam, the Netherlands j Department of Social and Behavioral Science, Harvard T.H. Chan School of Public Health, Boston, USA A R T I C L E I N F O Keywords: Cohort studies Child development Air pollution Neuroimaging Time series A B S T R A C T Air pollution exposure during early-life is associated with altered brain development, but the precise periods of susceptibility are unknown. We aimed to investigate whether there are periods of susceptibility of air pollution between conception and preadolescence in…

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